Cysteine 203 of Cyclophilin D Is Critical for Cyclophilin D Activation of the Mitochondrial Permeability Transition Pore
نویسندگان
چکیده
منابع مشابه
Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis.
Many of the cellular responses that occur in activated platelets resemble events that take place following activation of cell-death pathways in nucleated cells. We tested the hypothesis that formation of the mitochondrial permeability transition pore (MPTP), a key signaling event during cell death, also plays a critical role in platelet activation. Stimulation of murine platelets with thrombin ...
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Mammalian mitochondria contain an inner membrane pore which opens following an increase in matrix calcium. Pore opening has been implicated in tissue damage following ischaemic injury. The pore is reversibly blocked by cyclosporin A [l] suggesting a role for cyclophilin in pore control. A mitochondria1 isoform of cyclophilin (CyP-D) [2,3,4,5] has now been identified. Analysis of the N-terminus ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2011
ISSN: 0021-9258
DOI: 10.1074/jbc.m111.243469